Cytochrome P-450 CYP2E1

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

Also Known As:

CYP2E1; CYP 2E1; CYP IIE1; CYPIIE1; Cytochrome P-450 (ALC); Cytochrome P-450 IIE1; Cytochrome P-450-J; Cytochrome P450 2E1; N-Nitrosodimethylamine Demethylase; 4 Nitrophenol 2 Hydroxylase; Cytochrome P 450 CYP2E1; Cytochrome P 450 IIE1; Cytochrome P 450 J; Dimethylnitrosamine N Demethylase; N Nitrosodimethylamine Demethylase; 4-Nitrophenol-2-Hydroxylase; Dimethylnitrosamine N-Demethylase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 2: 31
        Cytochrome P-450 CYP2E1: 1317
    - Oxidoreductases Acting on CH-NH Group Donors
      - N-Demethylating Oxidoreductases: 18
        Cytochrome P-450 CYP2E1: 1317
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 2: 31
      - Cytochrome P-450 CYP2E1: 1317
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 2: 31
        Cytochrome P-450 CYP2E1: 1317

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Disease

Drug/Important Bio-Agent (IBA)